The Wheeler Difference
A paradigm shift in the path from discovery to manufacturing
Wheeler Bio is a biomanufacturing pioneer founded by a team of industry experts and strategic investors who believe a different CDMO model is needed for innovators to bring new therapeutic leads to the clinic faster, without the risk and cost associated with traditional outsourcing models. Our novel hub-and-spoke concept, centered in Oklahoma City with satellite labs embedded in discovery centers on the coasts, will revolutionize the translational path from discovery to CMC development and first patient dosing.
Oklahoma City (OKC) is an innovative biohub with an established biomanufacturing industry and clinical research network. Wheeler has built and operationalized state-of-the-art development labs and an innovative small scale CGMP manufacturing facility in the heart of OKC. Wheeler leverages powerful partnerships to offer a purpose-built development and manufacturing solution that employs advanced tech-stack solutions, with tremendously talented and experienced teams to deliver our clients from discovery to the clinic. Our platforms integrate with CROs’ discovery services to create a low-cost model, customizable models for translating innovation into clinical impact.
Wheeler’s pioneering, highly-accessible, open-source development platform – Portable CMC® – delivers speed to clinic and uniquely-affordable workflows by integrating discovery CROs and CDMOs.
Too often, innovators and their outsourcing providers have competing timeline horizons, budget expectations, and business priorities such that not all CMC (chemistry, manufacturing and controls) aspects are fully considered until it is too late. This can lead to delayed IND submissions or a clinical hold letter from the FDA, ultimately resulting in serious financial loss for innovators or even program failure. We believe these life cycle challenges can be alleviated with more flexible manufacturing platforms.
Portable CMC® is a suite-ready drug substance manufacturing platform that customers can transfer to any CDMO in the world with no royalties, licensing fees or penalties. By overlapping with the discovery workflow, Portable CMC® reduces timelines and regulatory risks through the introduction of QbD (Quality-by-Design) principles earlier on in the drug development life cycle.
Partnership defines Wheeler
To us, partnership means finding ways to share in the risks, share in the rewards, and share in the thrill of victory. Our open-source, transparent approach coupled with a fixed-payment model are examples of how our business favors partnering relationships over transactional ones. A deeply committed workforce also underscores our partnership culture. Wheeler employees are intentional and steadfast in delivering on their commitments, following through for the customer, seeking out solutions for challenges, and doing everything to ensure that Wheeler Bio is your most valuable partner.
Wheeler's Partnership Pledge
We serve people. We pledge always to strive for the highest level of client service by keeping the commitments we chose to make, following through for the client, investing in superior technologies that improve our processes, and leaving our clients with a profound sense of confidence in their choice to partner with us.
Wheeler Bio has strategically forged collaborations with a diverse array of industry leaders. These partnerships have enabled us to leverage cutting-edge genetic design and engineering capabilities, rigorous preclinical and toxicology testing, research insights, top-tier lab equipment and materials, and novel bioprocessing techniques and purification technologies, empowering our own team to deliver a faster, more reliable bioprocessing experience for the innovators we serve.
Dedication to Transparency
Wheeler’s culture embraces open communication and integrity. Employees aim to be authentic in every interaction and operate at the highest ethical and quality standards. This foundation is enhanced by a layer of digitalization tools that allow advanced data sharing, arming customers with instant insights for making critical decisions. Real-time, cloud-based data monitoring puts the customer on the development bench with Wheeler scientists for the ultimate collaborative CDMO experience. A rigorous project management layer ensures clarity of project status, regular customer contact, follow-ups, feedback, and rapid escalation routes.
All-in-One Fixed Development Pricing
An intentional prioritization on antibody drug substance development and manufacture allows Wheeler to offer more predictable project scopes, timelines, and budgets. Wheeler’s fixed development pricing includes the costs of raw materials, consumables, and third party services, eliminating hidden costs for the customer.
Wheeler offers two payment plans to fit your business needs:
- The traditional milestone plan invoices upon completion of milestone deliverables.
- The more predictable POC payment model invoices regular payments across the duration of a program allowing innovators to better predict cash flows and mutually align business priorities — solving for timelines instead of milestone based invoices.