Wheeler Bio is a biomanufacturing CDMO founded by a team of biologics development and manufacturing experts and strategic investors. Wheeler Bio believes a different CDMO model is needed to bring new therapeutic leads to the clinic faster, without the risk and cost associated with traditional outsourcing models.

Wheeler Bio is located securely in the heart of Oklahoma City (OKC), an emerging biohub with an established biomanufacturing industry and a clinical research network. Wheeler has built and operationalized state-of-the-art development labs and cGMP manufacturing facility there. The company relies on a tremendously talented and experienced internal team as well as strategic industry partnerships to deliver on the High-Science, High-Touch approach to advancing antibody-based therapeutics from discovery to development, drug substance and drug product manufacturing, regulatory support, and beyond.

Too often, innovators and their outsourcing providers have competing priorities, including timeline horizons, budget expectations, and business objectives that result in compromised or poorly achieved CMC (chemistry, manufacturing, and controls) objectives that are discovered too late. These misalignments can lead to delayed IND submissions and poorly designed manufacturing processes, ultimately resulting in serious financial loss for innovators or even program failure. The tactical CMC experts at Wheeler believe life-cycle risks can be avoided by deploying a modular approach from discovery to the initiation of Phase 1 clinical trials through solvent process design strategies and streamlined but sound CMC regulatory strategies

ModularCMC is a mammalian cell culture-based drug substance manufacturing platformthat reduces timelines and regulatory risks using QbD (Quality-by-Design) principles earlier in the drug development life cycle, and by breaking CMC activities into distinct work packages that create risk mitigation checkpoints rather than a one-size-fits-all solution.

Values define Wheeler

Wheeler's partnership culture is built on core principles that drive the work:

Teamwork encourages collaboration, where individuals bring their unique strengths and perspectives to work together toward common objectives.

Accountability ensures that each person takes responsibility for their role and actions, fostering a sense of ownership and reliability.

Transparency supports open communication, where all parties are informed, involved, and can rely on honest and clear exchanges of information in a timely manner.

Integrity asks each individual to act with honesty in all situations.

Excellence compels each team member to complete our work to the highest standards and to exceed expectations.

Together, these principles create an environment where partnerships thrive by cultivating a strong foundation of trust and shared responsibility, enabling teams to align, overcome challenges, and achieve collective success.

Wheeler’s culture embraces a High Touch communication style that engages client partners with integrity and openness. Employees aim to be authentic in every interaction and operate at the highest ethical and quality standards. This foundation is enhanced by a layer of digital tools that enable advanced data sharing, arming customers with instant insights to make critical decisions. Real-time, cloud-based data monitoring puts the customer on the development bench with Wheeler scientists for the ultimate collaborative CDMO experience. A rigorous project management approach ensures clarity of project status, routine customer contact, follow-ups, feedback, and rapid escalation routes.