CDMO Vision
Facilities
With a novel hub-and-spoke model, Wheeler Bio headquarters from its ultra-modern facilities located in Oklahoma City, with connections to coastal CROs to support drug discovery and development in well-established innovation and life sciences hubs.
Protein Sciences & Portable CMC® Lab
Boston, MA
Wheeler Bio’s cutting-edge Protein Sciences & Portable CMC® Lab, located within a CRO facility in Boston, is pioneering the development of revolutionary tools and processes with a focus on molecular biology, protein engineering, transient and stable pool-based protein production, underpinned by an alignment with Wheeler Bio facilities in Oklahoma for the efficient generation of preclinical materials.
Portable CMC® Services
Molecular Biology
Transient Protein Production in HEK or CHO Cells
Preclinical Material Supply & Testing from Stable CHO Pools
Advanced Cell Line Engineering
Integrated Process Development Lab
Oklahoma City, OK
Wheeler Bio’s Oklahoma City Development Center, located within the University of Oklahoma’s Research Park within the vibrant OKC Innovation District, offers a comprehensive suite of advanced biotechnology services. Through this state-of-the-art facility, the Wheeler team is at the forefront of cell line development, transient expression, protein production, process development, analytical development, formulation development, and preclinical material supply and testing.
Custom Development Services
Transient Protein Production in HEK or CHO Cells
Stable Cell Line Development
Preclinical Material Supply & Testing from Stable Pools
Process Development & Optimization
Process Characterization
Analytical Development & Qualification
Formulation Development
Preclinical Material Supply & Testing from Stable Clones
Small Scale CGMP Manufacturing Facility
Oklahoma City, OK
Wheeler Bio’s manufacturing center – within the “Ziggurat” building located in downtown Oklahoma City – is challenging the status quo by balancing risk with right-sized processes, and blazing the trails for other manufacturers to follow. With a sprawling 35,000 sq. ft. of dedicated CGMP clean-room space, Wheeler is redefining best practice by leveraging an open ballroom design, closed-process and digitally connected equipment for maximum flexibility, transparency, and speed.
GMP Services
CGMP Master Cell Banking
Grace C Solution Preparation
Grade D Ballroom Clinical Production (50L and 500L Scale)
QC Testing & Release Powered by Charles River RightSource℠ Technology
CGMP Drug Substance Manufacturing (500L Scale)